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Design and endpoints for clinical trials in primary sclerosing cholangitis

Patients start seeing results of the glutathione injections after at least 3weeks of the treatment

As a result, identical doses produce progressively weaker biological responses

Zhao J, Dong X, Hu X, et al

In parallel with these resistance trends, the global population of immunocompromised individuals, including patients with malignancies, transplant recipients, individuals with HIV infection, and those receiving immunosuppressive therapies, is steadily increasing, further amplifying the clinical burden and therapeutic complexity of resistant candidiasis (Sahu et al., 2026a