However, in some tumors, such as pancreatic cancer and melanoma, additional glutamine can inhibit the proliferation of tumor cells, and this mechanism is closely related to the regulation of the immune microenvironment
Mitochondria are the primary intracellular site of oxygen consumption and the major source of ROS, most of them originating from the ETC
Oxytosis/ferroptosis-(re-) emerging roles for oxidative stress-dependent non-apoptotic cell death in diseases of the central nervous system

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The localized accumulation of degradation products in the brain lowers the pH, promoting oxidative stress and neuroinflammation