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The resulting metabolite, 1,2,4-trichlorobenzene (1,2,4-TCB), is converted to less toxic chlorinated catechols (like 3,4,6-trichlorocatechol) by enzymes chlorobenzene dioxygenase/monooxygenase, which introduces hydroxyl groups to 1,2,4-TCB ring

In summary, multiple Mn transporters likely function synergistically to mediate the uptake and excretion of Mn in various tissues (Fig

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Immune reactions involving brain-specific proteins can influence clarity, focus, memory, and emotional steadiness

To clarify whether the first N-terminal residues of BNIP3 represent the discrete structural unit that directly can activate BAX, we conducted an established in vitro BAX activity assay utilising BNIP3-peptide 1-49, other BH3-only BAX activators (BIM and PUMA) as positive controls 38 , and bovine serum albumin and the antiapoptotic BCL XL as negative controls 2