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NPUN_R_XHOI (SEQ ID NO: 50) ATATAGCTCGAGATTCGGCAAATTATCAACCCG

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But the biology behind GHK-Cu anti-inflammatory signaling, antioxidant activity, and support for collagen and skin-barrier repair does overlap with what dermatologists target when managing flare-prone, reactive skin

wild-type (WT) was considered statistically significant

In specific embodiments, Ab is an anti-FRa antibodies which comprises the 6 CDRs which are 100% identical to corresponding CDRs of SEQ ID NO: 1-6, and the framework amino acid regions which are at least 90%, 91 %, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% identical to the corresponding framework amino acid regions as specified in SEQ ID NO: 7 and 8 respectively, wherein said anti-FRa antibody has the following properties: (i) it binds to the folate receptor receptor a (FRa) as determined by Elisa assay (as described in the Examples) with an EC50 below 5nM, for example about 0.5nM