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High Bioavailability : By avoiding the gastrointestinal tract and first-pass metabolism in the liver, drugs administered through the lungs can achieve higher bioavailability compared to oral administration (Although first-pass metabolism may occur in the lungs as well as other metabolically active tissues)

Hepatic lipid was extracted, as previously described (Folch et al

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The spirosuccinimide of ( S )-dHTC1 engages the IMiD-binding site of CRBN but, interestingly, it adopts a slightly different pose in the ternary complex compared to what was revealed by the cocrystal structure of the binary complex (Extended Data Fig

doi: 10.1016/S0891-5849(03)00062-5, 50