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Targeting ATP7B-mediated copper efflux and sEV secretion thus represents a promising approach to restore cuproptosis sensitivity and overcome chemoresistance in refractory OSCC

Thyroid patients who also carry certain FTO (fat mass and obesity-associated) variants or MC4R (melanocortin-4 receptor) polymorphisms often experience weight loss resistance even with optimized levothyroxine replacement

While collagen peptides help, copper peptides work directly on collagen remodeling

Injection of the autophagy inducer Tat-Beclin-1 increases mitophagy, reducing mitochondrial dysfunction, cardiomyocyte hypertrophy, and heart failure induced by pressure overload [73]