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Kyte, J

Under hypoxic conditions, pyruvate, a key glycolytic metabolite, is unable to efficiently enter the tricarboxylic acid cycle for complete oxidative metabolism

The corresponding pGV341 lentiviral expression vector or pGIPZ lentiviral non-target control shRNA (pGIPZ-NTC) transfected cells, MCF7/T47D VC or MDA-MB-231 NTC, were used as control cells 12