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30,32 The immunoregulatory role of GSH biosynthesis mediated by key enzymes such as Gclc and Gss has been well established in the regulation of macrophage inflammatory activation, monocyte redox-dependent cytokine production, and T cell differentiation

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Due to the high PUFA content in the brain, neurons are particularly vulnerable to ROS attack, leading to LPO and further ROS generationa vicious cycle that accelerates neurodegeneration

Doherty TM, Sher A, Vogel SN: Paclitaxel (Taxol)-induced killing of Leishmania major in murine macrophages

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