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Further research is needed to define subgroups of children with ASD in which these treatments may be most effective as well as confirm their efficacy in DBPC, large-scale multicenter studies

A randomised controlled trial to test the analgesic efficacy of topical morphine on minor superficial and partial thickness burns in accident and emergency departments

This distinction in transcriptional regulation, and the absence of a change to MT1 and MT2, suggests that decreased MT3 levels may not necessarily be a direct regulatory result of decreased copper levels but reflect parallel disease processes or broader copper dysregulation previously reported in the human ALS and MS spinal cord 15,16

The PubMed search also revealed that the pioneering use of transferrin receptor ligands for brain-targeting nanoparticle drug delivery systems was reported in 1996 by Huwyler et al