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doi: 10.1073/pnas.2104666118 58 BianchiMHakkimABrinkmannVSilerUSegerRAZychlinskyAet al

artesunate inhibits the cell growth in colorectal cancer by promoting ROS-dependent cell senescence and autophagy

GHK-Cu bezporednio stymuluje fibroblasty (komrki produkujce kolagen) do wzmoonej syntezy: Kolagenu typu I , gwnego biaka strukturalnego skry, cigien, wizade (+70 % w badaniach Maquart 1988) Kolagenu typu III , bardziej elastycznego typu dla tkanek regeneracyjnych Elastyny , biaka odpowiedzialnego za elastyczno skry Dekoryny i glikozaminoglikanw , hialuronianu, siarczanu dermatanu W dziedzinie dermatologii tumaczy to efekt przeciwzmarszczkowy GHK-Cu, przywrcenie struktury kolagenowej skry, ktra sabnie z wiekiem

This review systematically integrates the critical role of glutamine metabolism in tumor development and therapeutic resistance, providing new perspectives and translational pathways for the development of precision therapeutic strategy selection based on metabolic plasticity modulation