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Granzyme a from cytotoxic lymphocytes cleaves gsdmb to trigger pyroptosis in target cells

This structural change allows the peptide to remain active in an experimental environment far longer than natural IGF-1, providing a robust model for observing long-term anabolic signaling

Uricase nanocapsules extend the catalytic activity cycle of the enzyme, converting uric acid into readily excretable allantoin, whereas allopurinol nanoformulations enhance the inhibition of uric acid synthesis and the prevention of kidney stones through targeted delivery (Kandav et al., 2020

Our findings uncover an inflammatory, metabolically reprogrammed eosinophil population that promotes chronic skin inflammation by limiting protective T cell responses

Methods Enzymol 105:114120