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In general, ECs are connected side-by-side through transmembrane adhesion proteins [37], including vascular endothelial and neural cadherin at adherent junctions [38, 39], occludin [40], and members of the claudin family [41], as well as the junctional adhesion molecule (JAM) family at tight junctions [42]

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Disclosures: Huan Liang: Nothing to Disclose, Bobin Hu: Nothing to Disclose, Hang Wang: Nothing to Disclose, Hengkai Liang: Nothing to Disclose, Rongming Wang: Nothing to Disclose, Lu Wei: Nothing to Disclose, Tumei Su: Nothing to Disclose, Qingmei Li: Nothing to Disclose, Qianbin Yin: Nothing to Disclose, Yanfei Feng: Nothing to Disclose, Minghua Su: Nothing to Disclose, Jianning Jiang: Nothing to Disclose 425 SOLUBLE IMMUNE BIOMARKER PROFILING OF CHRONIC HEPATITIS B SUBJECTS TREATED WITH IMDUSIRAN IN COMBINATION WITH PEGYLATED INTERFERON ALFA REVEALS PHASES OF IMMUNE ACTIVATION Christine Espiritu 1 Sharie Ganchua 1 Timothy Eley 1 Kevin Gray 1 Man-Fung Yuen 2 Jeong Heo 3 Ronald Nahass 4 Grace Wong 5 Tatiana Burda 6 Kalyan Ram Bhamidimarri 7 Tsung-Hui Hu 8 Tuan T Nguyen 9 Young-Suk Lim 10 Chi-Yi Chen 11 Stuart Gordon 12 Jacinta Holmes 13 Wan Long Chuang 14 Anita Kohli 15 Naim Alkhouri 15 Angela Lam 1 Michael Sofia 1 Karen Sims 1 Emily Thi 1 , 1 Arbutus Biopharma, Warminster, PA, United States, 2 The University of Hong Kong, Queen Mary Hospital, Hong Kong, China, 3 Department of Internal Medicine, College of Medicine, Pusan National University, Busan, Rep of Korea, 4 ID Care, Hillsborough, NJ, United States, 5 The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China, 6 Arensia Exploratory Medicine, Chisinau, Moldova, 7 University of Miami Miller School of Medicine, Miami, FL, United States, 8 Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan, 9 Research and Education Inc, San Diego, CA, United States, 10 Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea, 11 Chia-Yi Christian Hospital, Chiayi City, Taiwan, 12 Henry Ford Health System, Detroit, MI, United States, 13 St.Vincent's University Hospital, University of Melbourne, Melbourne, Australia, 14 Kaohsiung Medical University Hospital, Kaohsiung City, Taiwan, 15 Arizona Liver Health, Chandler, AZ, United States Background: Functional cure of chronic hepatitis B (CHB) requires suppression of viral replication, reduction of HBV antigens and induction of anti-HBV immune response