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Yoshida et al

Typical Dosage Range Most protocols use between 600 mg and 1200 mg per session

doi: 10.1038/s41574-019-0156-z

This can leave mitochondrial membranes, enzymes and DNA more vulnerable to oxidative injury

Furthermore, during a stroke or heart attack episode, when the clogged artery is unblocked to save the patient, a sudden flow of oxygen (reperfusion) causes significant damage of the tissue via the oxidative stress process