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FIGURE 1 In the pathological process of AKI, apoptosis is mainly regulated in a coordinated manner through the mitochondrial pathway (endogenous apoptotic pathway), the death receptor pathway (exogenous apoptotic pathway), and the endoplasmic reticulum stress (ERS) pathway (Wang et al., 2022b

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However, long-term parenteral nutrition would lead to gut mucosal atrophy, gut-associated lymphoid tissue dysfunction and dysbiosis, all diminishing the immune functions of the gut and other organs, rendering the individual prone to life-threatening infections 277,278,279