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Resting-state fMRI studies of migraine without aura during the interictal phase have, in turn, reported altered intrinsic connectivity between the thalamus and the visual cortex [32], altered connectivity of specific thalamic subregions, including the anterior dorsal and ventral posterior nuclei, with the precuneus and pain-processing cortices [33], and abnormal dynamic thalamocortical network states [34]

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However, despite these promising findings, it remains unclear how chronic melatonin supplementation affects long-term health outcomes in shift workers

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