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Methods/design Study type This study takes the form a pragmatic, randomised, multicentre, non-inferiority clinical trial undertaken in the primary healthcare setting, with a duration of one year

Usually, the portal vein of such laboratory animals does not have culturable bacteria despite the presence of systemic sepsis, suggesting that BT takes place by transfer of intestinal bacteria predominantly into the lymphatic circulation via the intestinal lymph nodes, likely via the specialized M-cells overlying lymphoid aggregates [69, 70]