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Spain Glutathione Consumption 2021-2025 (MT) Figure 139

7.1 The combined delivery of antioxidants and chemotherapeutic agents Oxidative stress arising from chemotherapeutic agents is among the major difficulties that healthcare practitioners experience in cancer treatment

[3] In contrast, the diffusion of hydrophobic compounds across these barriers cannot be controlled, and organisms, therefore, cannot exclude lipid-soluble xenobiotics using membrane barriers

However, we have also pointed out some shortfalls in this evidence

1,2 Although the clinical trials of amitriptyline are old and involved small numbers of patients, a systematic review revealed that amitriptyline tended to show superiority over duloxetine, pregabalin, and milnacipran