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Free Radical Bio Med 71, 332338 (2014)

Additionally, Yan et al

The fact that the inhibitor of gamma-glutamylcysteine synthetase did not alter the response of glutathione is of importance, since it demonstrates that the increase of intracellular concentration of glutathione is not required to reduce the cell index

The second strategy of great importance is the development of mitochondria-targeted antioxidants that have shown a capacity to accumulate inside mitochondria, prevent mitochondrial oxidative damage, and attenuate mitochondrial dysfunction