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[] A recent study revealed that SMYD1, a striated muscle-specific histone methyltransferase, mediates the transcriptional activation of PGC-1 in the heart by increasing its promoter activity through the regulation of the levels of H3K4me3

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[10] [11] Intramuscular B12 injections (hydroxocobalamin or cyanocobalamin) bypass the digestive system, but UK product information (SmPCs) for hydroxocobalamin injections does list gastrointestinal disturbances, including diarrhoea, as possible adverse reactions, albeit rare