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Research comparing time-of-day administration for autophagy inducers shows consistent 2535% reductions in target engagement when dosed during circadian autophagy suppression windows

Senescence was induced with 100 nM 4-OHT for 7 days, while non-senescent cell controls were obtained by treating cells with DMSO

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Inhibitory effect of erinacines A on the growth of DLD-1 colorectal cancer cells is induced by generation of reactive oxygen species and activation of p70S6K and p21