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Mn-induced Nrf2 modulation was region-as well as sex-specific in rat brain (Zhang et al., 2017), suggesting that Mn dysregulates Nrf2 via various intracellular targets

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Antioxid Redox Signal 29(17):17561773

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Candidates who see the most clinical benefit tend to share a common profile: above-average visceral fat relative to their overall body composition, often in the context of metabolic syndrome, age-related GH decline, or prior hormonal disruption

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