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However, persistent ERS leads to sustained increases in intracellular Ca 2+ levels and long-term activation of the UPR, leading to mitochondrial dysfunction and triggering apoptosis to eliminate severely damaged cells (126)

Knutson SK, Kawano S, Minoshima Y, Warholic NM, Huang KC, Xiao Y, et al

Supplementing with L-carnitine can raise blood levels of TMAO which can potentially advance atherosclerosis

The study highlights that pesticides endocrine-disrupting (ED) properties can have varying adverse impacts on biological processes, including immunology, metabolism, and reproduction

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