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These two radicals are believed to be the main actors in peroxynitrite-related cellular damage.22 Besides, there are a couple of other reactive species that result from superoxide anion

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The retinal thickness, assessed by high resolution ultrasound, significantly decreased by 11% in mild cases and by 25% in moderate cases in Pycnogenol subjects

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For in vitro work, that usually means defining the final exposure in the assay system after dilution, vehicle contribution, contact time, and any adsorption losses to tubes or plates are accounted for