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In the blood stream as nicotinic acid, it can cause skin flush and this reaction is actually responsible for the tolerable upper limit (UL) for niacin at 35 mg/d for adults in US (20)

Journal of the American College of Cardiology 2002;39(7):1199-1203

ACSS2 drives senescence-associated secretory phenotype by limiting purine biosynthesis through PAICS acetylation

Human HCC is characterized by the dysregulation of several histone post-translational modifications (HPTMs), writers (HATS and KMTs), readers (BRDs), erasers (KDMs), and somatic mutations