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M.XunR.HuangY.ZhouH.SanchezE.et al (2010)

One of the major contributors in the inflammatory cascades is the high mobility group box 1 protein (HMGB1), which is overexpressed during neuroinflammation

The pirfenidone 2400-mg group had an intermediate change in eGFR ( 1.9 6.7 ml/min per 1.73 m 2 ) that was not significantly different from that of the placebo arm [221]

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