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3.3 The microenvironment of IVD The unique anatomical position and function of the IVD confer intrinsic physicochemical properties that create a challenging microenvironment for both resident and exogenously transplanted cells, potentially compromising their viability and functionality (Liang et al., 2012)

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The cytoplasmic tyrosine phosphorylation (P) sites of the c-Met are indicated: Tyr1003 is in the juxtamembrane binding site, Tyr1234 and Tyr1235 are in the active site of the kinase and Tyr1349 and Tyr1356 are in the bidentate docking site (Fig

Injection frequency considerations Unlike testosterone with its various ester formulations affecting release timing, HCG has a relatively short half-life requiring multiple weekly administrations