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ERAP1 controls the autoimmune response against melanocytes in psoriasis by generating the melanocyte autoantigen and regulating its amount for HLA-C*06:02 presentation

Since the gut is a gateway for environmental pathogens to enter, and the CNS and ENS participate in pathogen resistance mechanisms, the microbial flora and their metabolites are essential for promoting tight-junction expression and maintaining bloodbrain barrier (BBB) function ( Drosophila model of AD (Wu et al., 2017)

Approximately 15% of the nanoprobe crossed BBB and entered the brain parenchyma, which was much higher than the levels reachable by the traditional pathways 12,13

This leads to alterations in protein structure and function, such as PKC 74 (Figure 3)

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