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Compared to conventional imaging probes in the visible region, fluorescence imaging in the NIR-II region (10001700 nm) exhibits deeper tissue penetration and higher spatiotemporal resolution due to reduced tissue autofluorescence and photon scatter, enhancing accuracy and reliability in disease detection [13], [14], [15], [16], [17], [18]

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By contrast, GRK2 also negatively regulates 2 -adrenergic receptor [40] and dopamine D 1 receptor (D 1 R)/adenylyl cyclase signaling [41], which should result in vasoconstriction

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