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Sex-associated differences in the frequency of common oncogenic drivers exist, with a prevalence of FGFR2 alterations and IDH1 mutations in female patients with iCCA, while KRAS mutations are enriched in male patients with iCCA 55

The disorder may be especially severe or long lasting when the stressor is of human design (e.g., torture, rape)

In clinical studies, pharmacological supplementation of BH4 improves endothelium-dependent relaxations and augments NO-mediated effects on forearm blood flow in smokers and those with diabetes and elevated cholesterol [8588]

doi:10.1038/nprot.2006.59

Exp Mol Med (2020) 52:147585