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The expression of RAGE was significantly increased in patients with severe COVID-19, along with its ligands, including S100 and HMGB-1 (263, 264), and a system-wide transcriptomic analysis identified RAGE among the strongly upregulated genes in the liver, and among the slightly, but significantly upregulated genes in the heart and lymph nodes of COVID-19 patients (Supplementary Table S2 to (265))

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Mol Gen Genet 264:902912 Ott T, Van Dongen JT, Gunther C, Krusell L, Desbrosses G, Vigeolas H, Bock V, Czechowski T, Geigenberger P, Udvardi MK (2005) Symbiotic leghemoglobins are crucial for nitrogen fixation in legume root nodules but not for general plant growth and development

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Greater weight loss was seen with tirzepatide in the 72-week, phase 3 SURMOUNT study in people with obesity without T2D than in the SURPASS studies