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The progression of RA leads to synovitis and damages bone cartilage

doi: 10.12890/2020_001646 53 PolonikovA

10.1146/annurev-biochem-060809-095203 Annu

While early research provided a strong foundation, it was largely exploratory and not designed for risk assessment applications

Recent evidence shows regression of biopsy-proven advanced fibrosis and cirrhosis with iron removal [61, 129], where 70% of patients with F3 and 20% of patients with F4 fibrosis showed regression of fibrosis stage over a median follow-up of 9.5 years [61]