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Conventional oral administration faces limitations due to SFNs rapid metabolism and variable bioavailability

Pharmacokinetic studies in rodents have documented rapid absorption following subcutaneous injection (Tmax approximately 30 minutes), with distribution to multiple tissues including liver, kidney, skin, and lung

It is featured by a decrease in Lactobacilli and an elevation in other bacteria typically associated with BV (Pramanick et al., 2019)

Two trials in acutely hospitalized patients have shown that short-term (around 7 days) vitamin C supplementation increased concentrations of ascorbic acid in plasma and leukocytes and led to 34-35% improvements in mood state, as measured by POMS (142, 143)

The GAIN Act seeks to streamline the approval process for these repurposed drugs so that they can be given market clearance