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then, the cell nuclei were stained with Hoechst 33342

APOE 3/4 + PSEN1 fibroblasts show a higher number and clustering of lysosomes To determine whether the increase in autophagy induction contributes to further degradation of the mitochondria, we analyzed the final stage of the pathway, specifically, the distribution and number of lysosomes

2020;5(1):138.[DOI] 106

Notably, faster internalization does not necessarily translate to greater functional potency

Longer photostimulation times exhibited weaker HyPer7 responses, likely because of oxidative damage to the KR protein which prevented further photosensitization 27,32,33