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Oxidative stress can cause DNA damage, lipid peroxidation, protein oxidation, and mitochondrial dysfunction (81), all of which are associated with apoptosis in retinal ganglion cells

10.1016/0005-2728(96)00022-9 24 HirschhornT.StockwellB

These molecules act as DAMPs that activate immune responses, including the STING (stimulator of interferon genes) pathway in microglia, promoting an acute inflammatory phenotype and the release of pro-inflammatory cytokines such as TNF- and IL-1

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For example, an extract from Ficus carica, a plant native to the Mediterranean region transported by gold nanoparticles has been shown to reduce toxicity caused by cis-platin-induced oxidative stress (El-Sayed et al