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These cyanobacterial toxins are reported to cause death by liver haemorrhage within a few hours of the acute doses in mouse bioassays [160]

The inhibition of PI3K/Akt and ERK1/2 also significantly decreased NAMPT-induced VEGF expression and activation, leading to important inhibition of endothelial cell proliferation and in the formation of new vessels

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References Hartl FU, Bracher A, Hayer-Hartl M