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Methods A systematic review of the literature using the Pubmed, Embase, and Cochrane databases (search dates 1/1/1965 to 1/26/15) was conducted to identify peer-reviewed publications relevant to the diagnosis and treatment of PD

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On the other hand, the use of animal models to study invasive meningococcal disease, in addition to presenting the obvious difficulties in investigating aspects of the extracellular/intracellular phase of meningococcal infection, is hampered by the fact that meningococcus has a very narrow host specificity, essentially restricted to humans