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However, these cells convert rapidly to a pro-regenerative phenotype (Ly6C lo ) [103] that is essential for recovery by removing cell debris and promoting regeneration [104, 105]

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In the absence of any validated diagnostic criteria, clinicians sometimes inappropriately use the Assessment of Spondyloarthritis International Society (ASAS) classification criteria for axSpA for diagnosis, and this is unfortunately perpetuated in part by the statement in the abstract of the original paper describing the final selection of these criteria that they may help rheumatologists in clinical practice in diagnosing axSpA in those with chronic back pain. The diagnostic approach in clinical practice is aimed at the estimation of the probability of a suspected disease based on the patients clinical history, physical examination, investigations and the exclusion of alternative explanations that are not included in the ASAS classification criteria