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Acta Pharmacol Sin 2000

Birmingham host to investigational treatment trial which could improve outcomes of pregnancies affected by severe haemolytic disease [press release]

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B.WiseS

Clinically Important Drug Interactions with PPIs Reduced absorption due to gastric pH Azoles: Ketoconazole, Itraconazole, Posaconazole (oral) Antiretrovirals: Atazanavir , Rilpivirine Oral anticancer drugs (pH-dependent) Erlotinib, Gefitinib, Dasatinib, Nilotinib Iron salts, Calcium carbonate Mycophenolate mofetil Increased exposure / toxicity High-dose Methotrexate delayed clearance & toxicity Warfarin INR (monitor closely) Phenytoin, Diazepam Long-term safety concerns Hypomagnesemia (higher risk with diuretics) Clostridioides difficile infection Fracture risk with prolonged use Clinical Pearl Avoid unnecessary PPIs in patients receiving pH-dependent oral anticancer therapies