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Notably, it is difficult to calculate an accurate FDR using the entrapment strategy given that it is unlikely to know the exact number of phosphopeptides in the human sub-library that is not present in the sample

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However, it may also result from the existence and persistence of a subset of cancer cells that can survive initial receptor tyrosine kinase (RTK) inhibitor therapies and from which drug-resistant mutant cells eventually emerge to give rise to metastatic relapses [10,11,12,13]

Kincheloe, J