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Transglutaminase (TGase) catalyses the crosslink of proteins by forming e-(g-glutamyl) lysine isopeptide bonds and requires the binding of Ca2+ for its activity

The handful of studies sometimes cited as human evidence are largely case reports or small, uncontrolled pilot studies

It seems as though this significant change took place almost overnight

The observed increases with AMP (174 11%) and CAZ (152 7%) also suggest that these antibiotics similarly contribute to heightened oxidative stress

This genomic alteration enhances the sensitivity of cancer cells to low concentrations of SAM, a phenomenon observed in nasopharyngeal carcinoma (22, 24, 25)