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This process triggers ferroptosis, synergizes with photothermal therapy (PTT) by downregulating key ferroptosis suppressors GPX4 and FSP1, induces mitochondrial damage, and ultimately achieves complete tumor ablation

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Other isoforms, including GPX5, GPX6, GPX7, and GPX8, exhibit more specialised expression patterns and functions, some of which are still under investigation

Thirty-nine of the 94 TIR-NB-LRR-encoding genes identified by Meyers et al

It is estimated that 25% of the global population has NAFLD, a number projected to continue to rise, and as it does, it is expected that more of these cases will progress to end-stage disease states requiring liver transplantation