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Darius Alamouti und Team

SUPPLEMENTAL INFORMATION Supplemental information can be found online at STAR METHODS KEY RESOURCES TABLE EXPERIMENTAL MODEL AND STUDY PARTICIPANT DETAILS Mouse strains Protocols for all rodent experiments were approved by the Institutional Animal Care and the Animal Committee of Xiamen University (XMULAC20180028 and XMULAC20220050)

Recombinant human BIM (1325-BL-050) was obtained from RD Systems (MN, USA), recombinant human PUMA, His-tagged (PDEH100697) from Biomol (Germany), recombinant human BID (AS-617111) from AnaSpec (CA, USA), recombinant human BCL-2, His-tagged (HY-P7537) from MedChemExpress (NJ, USA) and GST-tagged (BCL2-1588HF) from Creative BioMart (NY, USA), recombinant human MCL-1, His-tagged (NBP2515100) from Novus Biologicals (Abingdon, UK)

This analysis revealed that SAM-modulating methyltransferases such as GNMT, PEMT, NNMT and COMT clustered with other highly tissue-specific methyltransferases ( Figure 1B )