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Time Frames: From baseline (week 0) to end of treatment (week 64)

The Spearmans correlation coefficients () were calculated to determine the correlation between GSH, GSH:GSSG ratio, and GPx activity, with each of these variables treated separately as the dependent variable and WC, BMI, and Hb as the independent variables

Direct water injection onto powder Squirting water directly onto the lyophilized powder creates impact force that damages peptide structure

Therefore, an increased supply of Met may increase antioxidant production, potentially aiding in the relief of oxidative stress and inflammation triggered by the production of reactive oxygen metabolites ( Conversely, Hcy has the capacity for remethylation to regenerate methionine, which relies on the folate cycle and vitamin B 12 ( Figure 1 ) ( 2 -THF), which is subsequently reduced to 5-methyltetrahydrofolate (5-CH 3 -THF) (Preynat et al., 2009)

Identification of nicotinamide Nmethyltransferase as a promising therapeutic target against diabetic cardiomyopathy