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These disturbances precipitate microbial dysbiosis, compromise epithelial barrier integrity, and activate aberrant immune responsesprocesses that interact through continuous bidirectional crosstalk rather than linear pathways

The first priority of treatment depends on actively identifying and treating all potential precipitating causes, such as infection, electrolyte disturbance, dehydration, etc., while managing the complications of encephalopathy

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The goal is usually two-fold: 1) Reduce inflammation and spasm in the piriformis muscle so it stops squeezing or irritating nearby structures

Nose-to-brain delivery of circular RNA SCMH1-loaded lipid nanoparticles for ischemic stroke therapy