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Jun 2024;42(6):1215-1223.doi:10.55563/clinexprheumatol/3l0ihz

Oxidative stress impairs the heat stress response and delays unfolded protein recovery

In the foundational 1996 dose-ranging study in healthy elderly subjects, oral MK-677 increased 24-hour GH concentrations in a dose-dependent manner roughly doubling mean GH at the 25 mg dose and the researchers attributed this to an enhancement of pre-existing pulsatile GH secretion : pulse height and interpulse nadir concentrations rose, while the number of pulses did not change significantly