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People who are most at risk of being B12 insufficient or deficient are vegans, vegetarians or those who do not eat much red meat older adults, individuals with atrophic gastritis, pernicious anemia, gastrointestinal disorders, those who have had gastrointestinal surgery + people who take certain medications including, but not limited to, birth control pills, H2 receptor antagonists (such as Tagamet, Pepcid + Zantac), PPIs (Proton Pump Inhibitors, such as Prilosec or Prevacid), Chloramphenicol (Chloromycetin) + Metformin

Equally important from a gerontological perspective, the SURMOUNT trials demonstrated substantial weight loss of approximately 15%20% at 72 weeks with tirzepatide, accompanied by visceral fat reduction and broad improvements in cardiovascular and metabolic risk factors, including blood pressure, fasting insulin, lipid profiles, and liver enzymes (Jastre et al., 2022)

It offers a novel approach to aging intervention by targeting telomeres, unlike traditional antioxidants that focus solely on free radicals