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Early diabetic neuropathy: triggers and mechanisms

Lysosomal damage is involved in various forms of cell death, such as apoptosis 6,7 , necroptosis 8,9 , pyroptosis 10,11 , and ferroptosis 12,13 , hinting that it is of great significance to the clarification of the potential mechanism of lysosomal damage and further exploration of efficient treatments based on lysosomal quality control (LQC)

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Loss of bone and Wnt10b expression in male type 1 diabetic mice is blocked by the probiotic Lactobacillus reuteri

We therefore hypothesised that CFTR inhibition in C38 cells would promote susceptibility to ferroptosis