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When NNMT is inhibited: NAD+ levels rise Mitochondria become more efficient Cells burn more energy, even at rest This effect helps the body shift into a more metabolically active state, making it easier to reduce fat and preserve muscle during weight loss

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This further supports the notion that promoting complete mitophagic flux, rather than just the initiation of mitophagy, could be critical in mitigating pancreatic inflammation and damage in AP

While a provider should confirm a deficiency first, certain groups tend to benefit most from a weekly schedule during active treatment