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True allergic reactions are rare

Malik, J

STZ-induced diabetic rats had significantly fewer autophagic vacuoles and an accumulation of autophagy substrates (103)

AOD-9604 is the most studied version: a Phase 2b obesity trial reported it was well tolerated with a safety profile comparable to placebo and no rebound weight gain, and it doesnt alter IGF-1 or glucose (BioSpace)