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The optimized solution suggested to increase the levels of the CoA transferase activity, CaiB, and the protein carrier, CaiT as the main targets to improve the L-(-)-carnitine production rate, predicting an enhancement of up to three times the initial productivity [108]

It plays a crucial role in energy production by transporting fatty acids into the mitochondria, where they are oxidized to produce ATP (adenosine triphosphate), the bodys primary energy currency

Lancet Neurol 11:521534 Abbott CA, Malik RA, van Ross E, Kulkarni J, Boulton A (2011) Prevalence and characteristics of painful diabetic neuropathy in a large community-based diabetic population in the UK

[18F]FDG PET signal is driven by astroglial glutamate transport

Glossary Abbreviations: ALC acetyl-l-carnitine BMI body mass index BP blood pressure DBP diastolic blood pressure GDR glucose disposal rate GFR glomerular filtration rate HbA 1c glycosylated hemoglobin HDL high-density lipoprotein HOMA-IR homeostatic model assessment of insulin resistance IQR interquartile range LDL low-density lipoprotein SD standard deviation SBP systolic blood pressure T2D type 2 diabetes Appendix 1 DIABASI Study Organization: Members of the DIABASI Study Organization were as follows: Principal InvestigatorN